Structure-Function Coupling

We posted our new manuscript on bioRxiv. Structure-Function Coupling Alignments with a Unimodal-to-Transmodal Gradient in the Mouse Cortex | bioRxiv. This work was done through collaboration with Ruixiang Li and Teppei Matsui (Doshisha University).

Brain networks are divided into structural connectivity (SC), formed by synaptic connections, and functional connectivity (FC), described by the synchronous activity of neurons. Studies on humans have shown that SC and FC do not necessarily correspond one-to-one, and the degree of coupling between SC and FC depends on the hierarchical structure of brain regions. In this study, we analyzed SC in the mouse cerebral cortex using datasets from the Allen Institute and FC by wide-field calcium imaging. We found that SF Coupling also depends on the hierarchical structure of the mouse cerebral cortex, which demonstrates that the hierarchical alignment of S-F coupling is conserved across species. As many studies report altered S-F coupling in neuropsychiatric diseases, our study may provide a new viewpoint for those studying the pathophysiology using rodent disease models.